【摘 要】
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Chiral organophosphine catalysts play an outstanding role in enabling the highly selective creation of useful skeletons for natural product synthesis.In 1997, Zhang groups was first to report the high
【机 构】
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State Key Laboratory and Institute of Elemento-Organic Chemistry, Collabortive Innovation Center of
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Chiral organophosphine catalysts play an outstanding role in enabling the highly selective creation of useful skeletons for natural product synthesis.In 1997, Zhang groups was first to report the highly enantioselective [3 + 2] cycloaddition reaction.[1] Afterwards, Fus groups reported highly enantioselective [4 + 2] annulations by using binaphthyl-based C2-symmetric phosphepines.[2] Recently, Lu, Zhao groups developed a series of simple amino acids-derived phosphine catalysts, which emerged highly enantioselective involving allenoates domino reaction.[3,4] In this reports, we reported a novel highly diastereoselective and enantioselective [2 + 3] / [3 + 2] cycloadditions between γ-substituent allenoates and 1-azadiene[5] catalyzed by N-acyl aminophosphines.
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