【摘 要】
：
目的：目前认为血清S100B蛋白是评估颅脑外伤的重要血清标志物,但非颅脑外伤是否可影响血清S100B蛋白尚有争议,故本研究的目的即探讨非颅脑外伤的创伤类型是否可影响血清中S100B蛋白的含量并分析可能存在的影响因素.方法：以我院急诊抢救室及急诊留观的325例创伤患者为研究对象,采集患者基本信息并于相应的时间点采集血液标本,将患者按是否存在颅脑损伤分为IHI组、NHI组、MTHI组,分析各组创伤患者
【机 构】
：
江苏南京 南京军区南京总医院急救医学科 南京大学医学院附属金陵医院 210002
【出 处】
：
2014北京协和急诊医学国际高峰论坛
论文部分内容阅读
目的：目前认为血清S100B蛋白是评估颅脑外伤的重要血清标志物,但非颅脑外伤是否可影响血清S100B蛋白尚有争议,故本研究的目的即探讨非颅脑外伤的创伤类型是否可影响血清中S100B蛋白的含量并分析可能存在的影响因素.方法：以我院急诊抢救室及急诊留观的325例创伤患者为研究对象,采集患者基本信息并于相应的时间点采集血液标本,将患者按是否存在颅脑损伤分为IHI组、NHI组、MTHI组,分析各组创伤患者血清S100B蛋白含量的差别,并分析四肢长骨骨折、失血性休克、ISS评分对非颅脑外伤患者血清S100B蛋白的影响.结果：在患者伤后3小时,MTHI组患者血清S100B蛋白高于IHI组以及NHI组(P＜0.01),而IHI组与NHI组相比无显著差异(p=0.126),而在创伤患者伤后6小时发现各组伤者血清S100B蛋白水平均较前提升(p＜0.001),且同样发现MIHI组血清S100B蛋白高于IHI组以及NHI组(P＜0.001),而IHI组与NHI组相比无显著差异(p=0.217),且非颅脑外伤患者中,四肢长骨骨折患者血清S100B蛋白水平高于非骨折患者,失血性休克患者血清S100B蛋白水平高于非休克患者,ISS评分》16分者其血清S100B蛋白水平高于ISS评分＜16分者.结论：非颅脑外伤可促使创伤患者血清S100B蛋白水平升高,而且失血性休克、四肢长骨骨折以及伤情严重程度均会影响血清S100B蛋白水平.
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