【摘 要】
:
Pulmonary hypertension is associated with increased oxidant stress,and production of reactive oxygen species(ROS)derived from both mitochondria and NADPH oxidases(NOX).ROS and changes in redox state a
【机 构】
:
Department of Physiology and Division of Asthma,Allergy & Lung Biology,King's College London,UK
论文部分内容阅读
Pulmonary hypertension is associated with increased oxidant stress,and production of reactive oxygen species(ROS)derived from both mitochondria and NADPH oxidases(NOX).ROS and changes in redox state are also implicated as the signalling moieties in the response to acute hypoxia,hypoxic pulmonary vasoconstriction(HPV).
其他文献
The initiation of human parturition is a complicated process,characterized by the crosstalk between mother and fetus.While the most studies focused on the mothers side,the contributions of fetus are l
Natural killer(NK)cells accumulate at the maternal–foetal interface in large numbers,but their exact roles in successful pregnancy remain poorly defined.Here,we provide evidence that decidual NK cells
The central processes in the medial pain system that are involved in mediating emotional responses to acute and chronic pain remain largely unresolved.In the medial pain system,high threshold afferent
Introduction: Pain has been the fifth vital sign in clinical care,and pain management is an important need in clinical quality care.As known chronic neuropathic pain and morphine tolerance,they are sh
The ability to experience and understand what others feel without confusion between self and others,plays a fundamental role in social interaction.Evidence from human studies implicates the anterior c
The ability to contract becomes impaired when skeletal muscles are activated at high rates or for long periods,i.e.fatigue develops.Altered Ca2+-handling has a key role in fatigue-induced functional i
Mechanical allodynia is a debilitating symptom associated with millions of chronic pain patients.It exists in two forms,dynamic and static,which are evoked by gentle skin touch and pressure,respective
Contraction of the heart results from the coordinated shortening of cardiac muscle cells,called cardiomyocytes.Contraction of cardiomyocytes is,in turn,dependent on sub-cellular structures called dyad
Disturbed calcium handling is a major predisposing factor for cardiac arrhythmias.Calcium handling in cardiomyocytes involves ion channels,transporters and pumps orchestrating two major calcium cyclin
With exposure to prolonged hypoxia,the pulmonary circulation responds with enhanced contraction and vascular remodeling,leading to increased pulmonary vascular resistance and development of pulmonary