β-diketones antibiotics(DKAs)are considered to be the main member of pharmaceuticals and personal care products,and their biological resistance becomes an indisputable fact due to their large production and wide usage.In recent years,the use of deep sequencing to study biological response of zebrafish in adverse circumstance has begun to increase.Herein,we report the identification of differential expression genes by deep sequencing when DKAs exposed to zebrafish.