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  5. Supression of CD4+ T cells by blocking Kv1.3 channels using Tityus serrulatus Ts6 and Ts15 toxins

Supression of CD4+ T cells by blocking Kv1.3 channels using Tityus serrulatus Ts6 and Ts15 toxins

来源 :10th IST Asia Pacific Congress on Animal , Plant and Microbi | 被引量 : 0次 | 上传用户：gyqg1q
【摘 要】
：
Tityus serrulatus (Ts) venom is composed by a mixture ofcomponents,which the neurotoxins are the main studied.The potassium channel neurotoxins Ts6 and Tsl 5 isolated from Ts venom have been studied b
【作 者】
：
M.B.Pucca F.A.Cerni T.B.Bertolini K.C.F.Bordon V.L.D.Bonato E.C.Arantes 
【机 构】
：
Laboratory of Animal Toxins,Department of Physics and Chemistry,School of Pharmaceutical Sciences of
【出 处】
：
10th IST Asia Pacific Congress on Animal , Plant and Microbi
【发表日期】
：
2014年5期
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论文部分内容阅读
Tityus serrulatus (Ts) venom is composed by a mixture ofcomponents,which the neurotoxins are the main studied.The potassium channel neurotoxins Ts6 and Tsl 5 isolated from Ts venom have been studied by our group and demonstrated to block Kvl.3 at picomolar concentration.The voltage-gated Kvl.3 potassium channel is a novel target for immunomodulation of autoreactive effector T cells that play a major role in the pathogenesis of autoimmune diseases.
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