靶向CXCR4新型多肽联合化疗药对急性髓系白血病的作用研究

来源 :中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：skylong5257

【摘要】

：

基质细胞衍生因子1(SDF-1,也称为CXCL12)主要是由骨髓基质细胞、内皮细胞等分泌的一种趋化因子,而其受体CXCR4在大多数白血病细胞表面高表达,因此,CXCR4/CXCL12轴可介导白血病细胞向骨髓基质中迁移及其与基质细胞的粘附,为白血病细胞提供促增殖、耐药等信号,是肿瘤细胞与其微环境相互作用的重要因子.

【作者】

：

郭花李潇谨杨延莲孟洁刘健王琛许海燕

【机构】

：

中国医学科学院基础医学研究所北京协和医学院基础学院,100005 国家纳米科学中心,100190

【出处】

：

中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议

【发表日期】

：

2014年6期

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靶向CXCR4新型多肽联合化疗药对急性髓系白血病的作用研究

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