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Objective To investigate the clinical features, pathologic changes and prognosis of 3 cases of Telbivudine-associated myopathy confirmed by muscle biopsy.Methods The medical records of 3 patients with were analyzed.Muscle biopsy was performed and cryostat sections were stained with H&E, modified Gomori trichrome (MGT), NADH-tetrazolium reductase (NADH-TR), succinate dehydrogenase (SDH), cytochrome C oxidase (COX), Oil red O(ORO) and periodic acid Schiff (PAS).The related literatures were reviewed.