Copper-Catalyzed Trifluoromethylation of Allylic Alcohols

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：jimzhan

【摘要】

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【作者】

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Xiaoxing Wu

【机构】

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Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,190 Kaiyuan Avenue,Guangz

【出处】

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The 24th International Society of Heterocyclic Chemistry Con

【发表日期】

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2013年4期

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An unprecedented copper-catalyzed trifluoromethylation-initiated radical 1,2-aryl migration in α,α-diaryl allylic alcohols has been disclosed, which allowed access to a variety of α-aryl β-trifluoromethyl ketones.The migratory aptitude on unsymmetrical substrates supports the trifluoromethyl radical mechanism, which was further confirmed by DFT calculations.

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Copper-Catalyzed Trifluoromethylation of Allylic Alcohols

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