鸡缺硒性心肌损伤中蛋白组学表达变化研究

来源 :中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 | 被引量 : 0次 | 上传用户：oyxz1988

【摘要】

：

硒是动物必需的微量元素，缺硒可引起鸡心肌损伤、炎症、糖代谢紊乱和胰岛素敏感性的改变。该试验通过高通量iTRAQ技术联合质谱鉴定的蛋白质学策略，动态研究并筛选鸡缺硒性心肌损伤中的蛋白组学的改变。结果显示，鸡缺硒性心肌损伤模型建立成功，心肌组织中共鉴定分析出2 877个蛋白，其中差异表达蛋白599个；应用Western Blotting以及RT-PCR对心肌组织进行表达验证可知，缺硒组心肌胰岛素通路相

【作者】

：

张子威姚海东徐世文

【机构】

：

东北农业大学动物医学学院临床兽医内科教研室,黑龙江哈尔滨150030

【出处】

：

中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会

【发表日期】

：

2015年4期

【关键词】

：

硒鸡心肌蛋白组学分析

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鸡缺硒性心肌损伤中蛋白组学表达变化研究

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