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目的 Obstructive sleep apnea (OSA) is associated with alterations in glucose metabolism.Untreated OSA may also deteriorate T2DM.Berlin Questionnaire (BQ) is effective to identify patients at high risk for OSA, however, its sensitivity and specificity in patients with glucose metabolic dysfunction remain unclear.Whether continuous positive airway pressure (CPAP) can act as an adjunct in diabetes control or insulin sensitivity needs to be determined.方法 121 patients with OSA symptoms were recruited for polysomnogram (PSG) and asked to complete Berlin Questionnaire (BQ), Pittsburgh Questionnaire (PSQI), and Epworth Sleepiness Scale (ESS).Patients were then scheduled the following morning for a 75 g oral glucose tolerance test (OGTT).According to the glycemic parameters, patients were divided into control, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) group for subgroup evaluation.Patients received CPAP treatment for 3 months, and were then recruited for OGTT.Statistical analysis with SPSS 22.0 was performed to study the diagnostic accuracy of BQ and the efficacy of CPAP therapy.结果 The sensitivity, specificity and accuracy of BQ in diagnosis of OSA with glucose metabolic dysfunction when AHI cut-off values are set at 5, 15, and 30, were： 72.29％, 100％, 72.62％； 76.92％, 100％, 78.57％； 76.92％, 47.37％, 70.24％, respectively.3 months of CPAP therapy effectively reduced the clinical symptoms and PSG parameters for all three groups, simultaneously improving OGTT results and HOMA-IR (P＜0.05).The improvement in glucose tolerance was more significant in the diabetes type Ⅱ group, with statistical significance (P＜0.05) for OGTT glucose levels, glycosylated hemoglobin, and decrease in HOMA-IR.结论 BQ is highly accurate in screening OSA patients with glucose metabolic dysfunction and can be considered an effective screening method.Further investigation of BQ in the diagnosis and management of mild to moderate OSAHS in patients with glucose metabolic dysfunction is promising.Treatment with CPAP can not only reduce OSA symptoms but also improve glycemic parameters.CPAP can be considered a treatment method for OSA with glucose dysregulation.