Synthesis and Biological Evaluation of Skimmin Derivatives

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：natural_jack

【摘要】

：

【作者】

：

Sheng-Peng Wang Xiao-Feng Wu Song Wu

【机构】

：

Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,1 Xian

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　Based on the novel anti-CRF activity of the lead compound skimmin,which was isolated from Hydragangea Macrophylla,a series of coumarin derivatives were designed and synthesized and their biological activities in vivo were evaluated by DDP (cisplatin) induced renal failure mice model.The results showed that a number of the title compounds exhibiting potent anti-CRF activity.This study provided several new lead compounds for the further development of anti-CRF agents that target renal tubulointerstitial.

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Synthesis and Biological Evaluation of Skimmin Derivatives

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