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5. Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design

Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：aj810130

【摘 要】

：

　　Recent outbreak of flavivirus Zika virus(ZIKV)in America has urged the basic as well as translational studies of this important human pathogen.The nonstruct

【作 者】

：

Caiying Zhang Tingting Feng Jinbo Cheng Yajuan Li Xueying Yin Weihong Zeng Xiangyu Jin Yuelong Li Feng Guo Tengchuan Jin 

【机 构】

：

LaboratoryofStructuralImmunology,UniversityofScienceandTechnologyofChina,Hefei,230027SchoolofMedicin

【出 处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

Flavivirus family virus Zika virus Methyltransferase RNA cap Antiviral inhibitor 

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论文部分内容阅读

　　Recent outbreak of flavivirus Zika virus(ZIKV)in America has urged the basic as well as translational studies of this important human pathogen.The nonstructural protein 5(NS5)of the flavivirus has an N terminal methyltransferase(MTase)domain that plays critical roles in viral RNA genome capping.

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