【摘 要】
：
With the high morbidity and mortality caused by cancer,finding more and better anti-cancer drugs is very urgent.In current research,biotransformation plays a vital role in the research and development
【机 构】
：
State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Med
【出 处】
：
2013年全国博士生学术论坛——中药资源系统研究与开发利用
论文部分内容阅读
With the high morbidity and mortality caused by cancer,finding more and better anti-cancer drugs is very urgent.In current research,biotransformation plays a vital role in the research and development of cancer drugs and has obtained some achievements.In this review,we have thoroughly summarized the four applications as follows:to exploit novel anti-cancer drugs,to improve existing anti-cancer drugs,to broaden limited anti-cancer drugs resources and to investigate correlative mechanism.Three different groups of important anti-cancer compounds would also be shown so as to clarify the current practical application of biotransformation in the development of anti-cancer drugs.
其他文献
目的:荨麻疹是一种临床常见的皮肤黏膜过敏性疾病。考查金蝉止痒胶囊的抗过敏、抗炎作用.方法:以2,4二硝基氯苯致小鼠迟发性超敏反应、大鼠同种被动皮肤过敏反应和对大鼠颅骨肥大细胞脱颗粒作用观察抗过敏作用;采用二甲苯致小鼠耳肿胀、大鼠皮肤毛细血管通透性亢进及大鼠蛋清性足肿胀实验,探讨抗炎作用.结果:金蝉止痒胶囊能显著的抑制小鼠迟发性超敏反应和大鼠同种被动皮肤过敏反应,阻止大鼠颅骨肥大细胞脱颗粒,对小鼠耳
目的:考察健脾止泻宁颗粒的助消化、促吸收作用,为其临床应用提供实验依据.方法:采用健脾止泻宁颗粒对番泻叶致幼龄大鼠脾虚泄泻模型胃液分泌和胃蛋白酶活性的影响、对幼龄脾虚泄泻大鼠血清淀粉酶活性的影响来评价其助消化作用;采用健脾止泻宁颗粒对正常小鼠与幼龄脾虚泄泻大鼠木糖吸收的影响来评价其促吸收作用.结果:与模型组比较,健脾止泻宁颗粒高、中剂量组胃液分泌量显著增高,具有显著的统计学意义(P＜0.05),健
Rhizoma Coptidis is a traditional Chinese medicine mainly consists of protoberberine alkaloids(PAs).Recent research revealed the various pharmacological activities of Rhizoma Coptidis,and the antitumo
Paeoniflorin,one of the primary bioactive components in Chi shao,are widely used in traditional Chinese medicine.A lot of evidences suggest that Paeoniflorin has potential anti-oxidant effects.However
Pogostemonis Herba is well known to be used as Chinese herbal medicine to remove dampness,relieve sunstroke,stop vomiting and stimulate the appetite.Patchouli alcohol is the most active ingredient in
It is a common sense that chewing a mint leaf causes a cold feeling,while masticating a piece of ginger root is associated with a hot sensation.The Traditional Chinese Medicine has termed this phenome
目的:研究五灵脂粉体特性,为制剂及质量研究提供依据.方法:采用振动式低温超微粉碎机对五灵脂进行粉碎,每3min取样,检测样品粒径、比表面积、孔隙率及体外溶出速率.结果:随着粉碎时间的增加,粒径逐渐减小,比表面积及体外溶出速率逐渐增加;粉末粒径与体外溶出速率具有良好相关性.结论:五灵脂低温超微粉碎后不仅粒径小,粒子形态及结构均匀,且溶出速率快,有助于后续制剂及质量研究.
Objective:To study the rational daily administration times of Canhuang Tablet(CHT)for treating jaundice in rats based on pharmacodynamics/pharmacokinetics model.Methods:Rats were modeled by 4% 1-Napht
The anti-bacterial activity of a kind of novel peptide from Plutella xylostella(pxCECA1),on methicillin resistant staphylococcus aureus(MRSA)and Escherichia coli(E.coli)growth were investigated by mic
目的:通过研究7种大孔吸附树脂对补肾益寿胶囊水提取液的精制工艺,筛选大孔吸附树脂型号.方法:建立补肾益寿胶囊五味药材的水提取液HPLC指纹图谱,以选定的10个色谱峰为指标,并结合70％乙醇洗脱液干膏收率优选大孔吸附树脂型号.结果:Seplite LX-66型大孔吸附树脂对10个指标成分具有较好的吸附性能和解吸效果,且70％乙醇洗脱液干膏收率最低、精制效果最好.结论:Seplite LX-66型大孔