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Background In 2009 two blinded placebo-controlled trials were publicated to question the efficacy of vertebroplasty comparing with sham treatment (ST) in the New England Journal of Medicine,which provoked an academic debate on the efficacy of PVA.The purposes of our study were to answer these questions:Is there a clinical difference in pain relief,functional improvement,and overall quality of life between PVA and CT for painful osteoporotic VCFs? In addition,are the results maintained over long time points?