【摘 要】
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Background, Motivation and Objective Many vessel pathologies of interest (such as plaques and aneurysms) cause focal changes in the wall properties.Therefore, a method to accurately estimate spatially
【机 构】
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Biomedical Engineering, Columbia University, New York, New York, USA
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Background, Motivation and Objective Many vessel pathologies of interest (such as plaques and aneurysms) cause focal changes in the wall properties.Therefore, a method to accurately estimate spatially varying mechanical properties is required.Pulse wave imaging (PWI) images the propagation of intrinsic pulse waves along the vessel wall.Modeling can predict reflections and changes in the waveform caused by inhomogeneities; a full 3D fluid-solid interaction model including both blood flow and vessel wall motion comes at a prohibitive computational cost, but in many cases a 1D approximation is reasonable as the blood velocity along the vessel is much larger than the radial components.This work presents a 1D pulse-wave inverse problem, where a set of spatially discretized unknown properties and boundary conditions of the governing 1D partial differential equations are found which provide the most accurate match between the model and the spatiotemporal vessel wall displacements measured by PWI.
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