Overexpression of TAGLN in Tumor Stroma Increases Gastric Cancer Metastasis Via Tumor-stromal Intera

来源 :2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会) | 被引量 : 0次 | 上传用户：book_008

【摘要】

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【作者】

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Xiaoqing Zhang Xuehua Chen Binya Liu Qu Cai Zhenggang Zhu

【机构】

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Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Second Medical University, Shangh

【出处】

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2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)

【发表日期】

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2005年12期

【关键词】

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gene expression profiling tumor stroma gene transfer TAGLN animal model

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　　Background & Aim:Gastric cancer is the second leading cause of cancer death in the world.Lymph node metastasis is a significant prognostic factor in gastric cancer.Recently,tumor-stromal interaction showed to be involved in many malignant phenotypes,including tumor metastasis.We have carried out a systematic study ofgene expression in gastric adenocarcinoma and nonneoplastic gastric mucosa.The expression of TAGLN,gene coding a actin-binding protein,was found to be highly associated with lymph node metastasis.In this study,we aimed to examine the role of TAGLN in invasion and metastasis of gastric cancer.

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Overexpression of TAGLN in Tumor Stroma Increases Gastric Cancer Metastasis Via Tumor-stromal Intera

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