【摘 要】
：
Glutathione S-transferases (GSTs) are a class of enzymes that facilitate the detoxification of xenobiotics,and also play important roles in antioxidant defense.In this study,two glutathione S-transfer
【机 构】
：
Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences,Yantai,264003,China;The Gradua
【出 处】
：
中国科学院“百人学者论坛”2010年学术年会
论文部分内容阅读
Glutathione S-transferases (GSTs) are a class of enzymes that facilitate the detoxification of xenobiotics,and also play important roles in antioxidant defense.In this study,two glutathione S-transferase isoforms (RpGSTS,sigma GST; RpGSTO,omega GST) were cloned from Manila clam (Ruditapes philippinarum) by RACE approaches.The expression profiles of RpGSTS and RpGSTO responded to heavy metals and benzo[a]pyrene exposure were investigated by quantitative real-time RT-PCR.The expression of RpGSTS and RpGSTO were both rapidly up-regulated,however,they showed different expression patterns to different toxicants.The expression level of RpGSTS in haemolymph with Cd exposure increased much higher than that of RpGSTO,while there existed similar expression patterns for both RpGSTS and RpGSTO from Cu exposed group.For B[α]P exposure,the maximum induction of RpGSTO was approximately two times higher than that of RpGSTS.Taken together,RpGSTS exhibited to be potentially a sensitive biomarker for Cd exposure,while RpGSTO could serve as a marker of B[α]P in environmental monitoring programs.
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