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  5. Toll-like receptor 4 signaling in neurons of trigeminal ganglion contributes to pain induced by acut

Toll-like receptor 4 signaling in neurons of trigeminal ganglion contributes to pain induced by acut

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：luohuixian11
【摘 要】
：
Pain caused by acute pulpitis(AP)is a common symptom in clinical settings.However,its underlying mechanisms have largely remained unknown.Using AP model,we demonstrated that dental injury caused sever
【作 者】
：
Jia-Ji Lin Wen-Ke Cai Yi Du Rong Kuang Ting Chang Zhuo Zhang Yong-Xiang Yang Chao Sun Zhu-Yi Li Fang Kuang 
【机 构】
：
Department of Neurobiology,Institute of Neurosciences of PLA,The Fourth Military Medical University,
【出 处】
：
The 6th FAONS Congress and 11th Biennial Conference of CNS(第
【发表日期】
：
2015年3期
【关键词】
：
Toll-like receptor 4 acute pulpitis orofacial pain pain sensation trigeminal gan 
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　　Pain caused by acute pulpitis(AP)is a common symptom in clinical settings.However,its underlying mechanisms have largely remained unknown.Using AP model,we demonstrated that dental injury caused severe pulp inflammation with up-regulated serum IL-1β.Assessment from head-withdrawal reflex thresholds(HWTs)and open-field test demonstrated pain sensation at 1 day.
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