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A facile and eco-friendly strategy for synthesis of graphene-supproted hydroxyapatite nanorod composites was described.The as-obtained products were characterized by the X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),field emission transmission electron microscopy(FETEM),Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)as well as Thermogravimetric analysis(TGA).The results showed that rod-like hydroxyapatite particles strongly anchored on both sides of graphene.In addition,the influence of graphene/HA nanorod on the proliferation and differentiation of MC3T3-E1 cells was also investigated by various of biological approaches,indicating these composites had good biocompatibility and induced excellent bone cell proliferation.The remarkable biocompatibility of the composites makes them promising candidates for applications in bone regeneration and implantation.