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Background/Aims:Theslowhealingprocessoftendon-to-bonejunctionscanbeacceleratedviaimplantedtendon-derivedstem cells(TDSCs)withsilencedtransforminggrowthinteractingfactor1(TGIF1)gene.Tendon-to-boneinsertionsiteisthespecial formofconnectivetissuesderivativesofcommonconnectiveprogenitors,whereTGF-βplaysbidirectionaleffects(chondrogenic orfibrogenic)throughdifferentsignalingpathwaysatthedifferentstages.