【摘 要】
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Background:Non-alcoholic fatty liver disease(NAFLD),ranging from nonalcoholic fatty Liver(NAFL) to progressive non-alcoholic steatohepatitis(NASH) and fibrosis,has become an increasingly common health
【机 构】
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Shanghai Ruijin Hospital
【出 处】
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2014年APASL专题会议暨第四届乙型病毒性肝炎专题会议
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Background:Non-alcoholic fatty liver disease(NAFLD),ranging from nonalcoholic fatty Liver(NAFL) to progressive non-alcoholic steatohepatitis(NASH) and fibrosis,has become an increasingly common healthy problem.SENP3,a sentrin/de-SUMO specific protease,plays an important role in spectrum of cellular process.Reports have demonstrated that SENP3 was sensitive to a variety of stresses.However stresses such as oxidative stress,lipid accumulation,cytokines,et al,have been known as major factors involved in the development of NAFLD.Thus,the aim of this study was to investigate if and how SENP3 was involved in NAFLD.
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