Introduction.Mechanosensory osteocytes (OYs) are the most abundant and long-lived (up to decades) cells entombed in bone.The longevity of osteocytes is achieved, in part, by their unique ability to adapt to enviromental and chemical stresses and elicit cell survial response mechanisms, e.g.autophagy;among which Redd 1-mTORC1 is rapidly emerging as key regulators.