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Objective:The purpose of this study was to evaluate the effect of different dose midazolam through the change of bispectral index (BIS) during cardiopulmonary bypass (CPB),Methods:Forty-five ASA Ⅱ or Ⅲ patients of both sexes (23 male,22 female) aged 6 months to 3 years scheduled for elective ASD or VSD neoplasty and CPB.