【摘 要】
：
In order to maintain their malignant phenotype, neoplastic cells must neutralize most of their tumor suppressor (TSP) and growth regulatory (GRP) proteins.C
【机 构】
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Karyopharm Therapeutics Inc.USA
论文部分内容阅读
In order to maintain their malignant phenotype, neoplastic cells must neutralize most of their tumor suppressor (TSP) and growth regulatory (GRP) proteins.CRM1, also called exportin 1 (XPO1), is a key nuclear export protein which controls the location of multiple tumor suppressor (TSP) and growth regulatory (GRP) pathways including p53, PI3K/AKT/FOXO, Wnt/β-catenin/APC and NF-kB/IkB.Inappropriate cytoplasmic localization can abrogate TSP/GRP functions and render chemotherapies ineffective.
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