CRTC2 Controls Hepatic Lipid Metabolism by Regulating SREBP1

来源 :北京细胞生物学会2015年学术大会 | 被引量 : 0次 | 上传用户:zzfsunny
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Abnormal accumulation of triglycerides in the liver, caused in part by increased de novo lipogenesis, results in nonalcoholic fatty liver disease and insulin resistance.Sterol regulatory element-binding protein 1 (SREBP1), an important transcriptional regulator of lipogenesis, is synthesized as an inactive precursor that binds to the endoplasmic reticulum (ER).
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