We analyzed the disturbance anomaly in the global ionosphere TEC caused by Coronal mass Ejection on May 23, 2017,based on the GPS ionosphere detection technology. Affected by the Coronal mass Ejection toward Earth, The ionosphere TEC first has a disturbance anomaly on May 23 2017. 20 oclock. Because of the earth rotation, the ionosphere TEC anomaly area would move to the west along with the sun point-blank point. The ionosphere TEC disturbance maximum is 21TECU.In addition, we analyzed the influence of the Coronal mass Ejection on the correction effect and positioning accuracy of the ionosphere model of the IGS GPS monitoring station. The result shows that the Coronal mass Ejection has the greatest impact on the correction of the GPSK8 model, and the impact on the positioning accuracy of monitoring stations are 2-5m.