【摘 要】
：
Several earlier reports demonstrated that maternal zinc deficiency during pregnancy was linked with adverse pregnant outcomes.Nevertheless,it needs to be determined whether maternal zinc deficiency du
【机 构】
：
Department of Toxicology,Anhui Medical University,Hefei,China
【出 处】
：
中华预防医学会自由基预防学专业委员会2014年学术交流会议
论文部分内容阅读
Several earlier reports demonstrated that maternal zinc deficiency during pregnancy was linked with adverse pregnant outcomes.Nevertheless,it needs to be determined whether maternal zinc deficiency during pregnancy elevates the risk of low birth weight(LBW)and small for gestational age(SGA)infants.The objective of this study was to investigate the association between maternal zinc level during pregnancy and the risks of LBW and SGA infants in a large population-based birth cohort study.This study was a population-based prospective cohort study that recruited total 3187 eligible mother-and-singleton-offspring pairs.The association between maternal zinc level during pregnancy and the risks of LBW and SGA infants was analyzed.For serum zinc level,2940 pregnant women(92.2%)were sufficient(≥56 μg/dl)and 247(7.8%)deficient(<56 μg/dl).Of interest,7.3%newborns were with LBW among subjects with low zinc level(RR: 3.48; 95%CI: 2.03,5.96; P=0.000).Adjusted RR for LBW was 3.55(95%CI: 2.07,6.11; P=0.000)among subjects with low zinc level.Moreover,15.0%newborns were with SGA among subjects with low zinc level(RR: 1.98; 95%CI: 1.36,2.88; P=0.000).Adjusted RR for SGA was 1.98(95%CI: 1.36,2.89; P=0.000)among subjects with low zinc level.A nested case-control study within above cohort showed that serum zinc level during early gestational stage was lower in LBW cases as compared with controls.By contrast,serum TNF-α and IL-8 levels were significantly higher in LBW cases than that of controls.Moreover,nuclear NF-κB p65 was significantly up-regulated in placentas of SGA cases as compared with controls.In conclusion,maternal zinc deficiency during pregnancy elevates the risks of LBW and SGA infants.Further research is required to determine the benefits of large-scale zinc supplementation in pregnant women.
其他文献
目的：观察使用自体动静脉内瘘(arteriovenous fistula,AVF)进行维持性血液透析(maintenance hemodialysis,MHD)患者的内瘘血流量(Qa)、心输出量(CO)和平均动脉压(MAP)的变化.了解影响内瘘血流量的危险因素.方法：1.入选患者54例.采用超声稀释法观察血液透析(HD)过程中透析开始后30分钟、120分钟和180分钟三个时间点Qa、CO、MAP的
目的 探讨线粒体DNA(mitochondrial DNA,mtDNA)D环(displacement loop,Dloop)区域基因多态性与慢性肾脏病(chronic kidney disease,CKD)发病风险的关系. 方法 应用病例对照研究,选择82例CKD5期患者和159例健康人作为研究对象,所有CKD患者均满足一定入院标准及排除标准,本实验经河北医科大学第四医院伦理委员会批准,所有患者
目的 探讨品管圈活动在血透中心护士手卫生管理中的应用与效果.方法2013年3月～2014年2月将品管圈活动应用于血透中心护士的手卫生管理中，分析影响血透中心护士手卫生遵从率与正确性的因素，制定相应的对策并实施，同时评估活动的效果.结果 开展品管圈活动后，血透中心护士手卫生遵从率由41.02％提高到88.46％，洗手正确率由46.88％提高到91.30％，差异均有统计学意义(P＜0.05).同时，圈
目的 应用血管回声跟踪技术(echo-tracking,ET)对终末期肾脏病(end-stage renal disease,ESRD)患者的颈总动脉及桡动脉弹性进行评价,初步判定ESRD患者动脉硬化的灵敏指标,并且确定诊断ESRD患者动脉硬化的截断值。方法 应用ET技术检测34例ESRD患者颈总动脉及桡动脉弹性参数,并与30例健康正常人的动脉弹性参数进行分析比较,初步确定ESRD患者动脉硬化ET
肾脏是调节人体血磷平衡的重要器官,肾功能下降时,肾脏对磷的排泄功能降低,导致血磷水平逐渐升高;肾功能下降时,近曲小管产生骨化三醇减少,致低钙血症和骨代谢异常的发生.血磷升高促进继发性甲状旁腺功能亢进、加重体内钙磷代谢紊乱、促进血管钙化,最终导致肾衰患者死亡率增加.我国针对透析患者进行的矿物质和骨代谢异常的多中心研究显示:维持性血液透析患者血钙、血磷、血iPTH水平不达标的比例分别为:42 ％、57
Objective To investigate the clavicular hook plate of the Zimmer self- lock wire- rope compared the clinical analysis of efficacy in the treatment of acromioclavicular joint dislocation and evaluation
Objective Through the development of "construction management in Department of surgery ward thrombosis" joint,thrombus prevention standard vein,reduce Department of orthopedics after operation for ven
Department of Orthopaedics,The First Affiliated Hospital of China Medical University,Shenyang City,Liaoning 110001,China Objective Our research is to transplant temporary tumorigenesis bone marrow mes
Objective To evaluate the potential protective effects of extracts from fructus rhodomyrti(FR)against oxidative DNA damage using a cellular system,and the antioxidant ability on potassium bromate(KBrO
It is increasingly recognized that intra-uterine growth restriction(IUGR)is associated with an increased risk of metabolic disorders in late life.Previous studies showed that mice exposed to LPS in la