2. 您的位置
3. 首页
4. 会议论文
5. Impact of the linker structure on the combination therapy of polymeric conjugates

Impact of the linker structure on the combination therapy of polymeric conjugates

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：qq4156500

【摘 要】

：

Recently a great effort has been made to perfect the therapeutic effect of solid tumor,from single-agent therapy to combined therapy and polymer-drug conjugates with dual or more anticancer agents due

【作 者】

：

Yu Cao Shiying Luo Yuannian Zhang Xuan Xie Jean Felix Mukerabigwi Wang Xiao Xueying Huang Ping Su 

【机 构】

：

Key Laboratory of Pesticide and Chemical Biology (Ministry of Education),College of Chemistry,Centra

【出 处】

：

Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

：

2016年11期

【关键词】

：

polymer-drug conjugats amide bond peptide bond combination therapy 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Recently a great effort has been made to perfect the therapeutic effect of solid tumor,from single-agent therapy to combined therapy and polymer-drug conjugates with dual or more anticancer agents due to their good synergistic effect and higher drug accumulation level towards tumor tissues[1].

其他文献

Synthesis of poly(fluorenyl-alt-p-phenyleneethynylene) with pendent carboxyl acid group and the sens

Fluorescent conjugated polymers with pendent functional groups have attracted great interest as sensing materials[1,2].A new fluorescent conjugated polymer with pendent carboxyl acid groups and poly[f

会议

conjugated polymerfluorescencesensingfluorenylbuilding block

Oxidized hyaluronic acid modified by L-Argine for siRNA delivery

Small interfering RNA (siRNA) delivery is considered as a promising tool for tumor ablation.Among so many carriers used in siRNA delivery,non-viral carriers possess significant potential due to their

会议

oxidized hyaluronic acidL-ArginesiRNA deliverynegatively charged

Poly(iron(Ⅲ)-catecholate) micellar nanoparticles as MRI contrast agents

Current Gd-based MRJ contrast agents suffer from toxicity spurring a resurgence of interest in Gd-free MRI agents[1].Towards this goal,we have developed a new class of efficient and biocompatible MRI

会议

MR imagingpolycatecholmicellerelaxivitysynthetic melaninGd-free agents

pH-triggered mesoporous silica nanocomplexes for imaging-guided drug delivery with enhanced cancer t

Integrating biological imaging and drug therapy into one platform has been of great interest in the field of nanomedicine.Therefore,development a suitable imaging agent for simultaneous drug delivery

会议

pH-triggeredmesoporous silica nanocomplexesUltrasound imagingdrug delivery

A thermo-degradable hydrogel for on-demand drug delivery

Hydrogels have been used for a wide range of biomedical applications,such as vehicles for drug and gene delivery,scaffolds for tissue regeneration,and bioadhesive glues for surgical sutures[1].

会议

smart hydrogelthermo-responsivenear-infrared lightlight-tunabledrug delivery

In situ bone regeneration by mechanics-modified scaffolds loaded with chemokine

An attractive alternative in bone tissue engineering is to harness the potential of endogenous stem/progenitor cells for direct use in repair and regeneration.This strategy can effectively avoid the l

会议

matrix stiffnesstopologystromal cell-derived factor-1αhigh mobility group box

Ezrin-targeted calcium (Ⅱ)-crosslinked nanoparticle intracellularly co-delivers doxorubicin and chlo

Osteosarcoma is a type of serious malignancies,which is almost suffered by children and adolescents.Unfortunately,lacking of specific and effective treatments like desirable chemotherapeutics always l

会议

polypeptide nanoparticleezrin-targetingsynergistic effectcontrolled drug deli

Tunable emission of QDs upon near-infrared excitation through fluorescence resonance energy transfer

For more than two decades,research on semiconductor nanocrystals,also known as colloidal quantum dots (QDs),has dominated the field of nanomaterials[1].However,in general,these QDs,especially Ⅱ-Ⅵ semi

会议

quantum dotsupconversion nanoparticlesFRETNIR excitation

Injectable and release-controlled hydrogel based on xanthan gum and silk fibroin

Fabrication of three dimensional regenerative tissues with self-supporting architectures from ECM-like hydrogels has gained much attention in tissue engineering.

会议

injectable hydrogelxanthan gumsilk fibroindrug delivery

Design and fabrication of TPP cross-linked chitosan hydrogels with tunable stimuli-responsive proper

Stimuli-responsive hydrogels,which can undergo abrupt volume change in response to small environmental changes including temperature,pH,and ionic strength,etc.,are of great interest in drug delivery,c

会议

TPP cross-linkingchitosan hydrogelcontrolled stimuli-sensitivity