Aims: The proinflammatory cytokines IL-12 and IL-23 connect innate immunity to adaptive immune responses and are also involved in autoimmune and inflammatory diseases.
TANK-binding kinase 1 (TBK1) activation is a central event in type I interferon production in anti-virus innate immunity.However, the regulatory mechanism underlying TBK1 activation remains unclear.
Since 2013, the emergence of an avian-origin influenza A (H7N9) virus has raised concern in China.Although most infections resulted in respiratory illness, some severe cases resulted in acute respirat
Aim: Although natural killer (NK) cells are classified as innate immune cells, recent studies demonstrate that NK cells can become long-lived memory cells and contribute to secondary immune responses
Meta-inflammation is responsible for several metabolic syndromes, although the mechanism by which metabolic disorders trigger meta-inflammation remains unclear.
Microbial exopolysaccharides (EPSs), long-chain polysaccharides released by a variety of organisms, have gained considerable attention for their potential in multiple disease treatments.
Rationale: Severe combined immunodeficiency (SCID), a rare PID, is poorly characterized in China.We retrospectively reviewed patients with SCID refered to our hospital from 2004 to 2013, and summarize
Objective: Mutations in gone ZBTB24 lead to autosomal-recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome in some patients.