Andrographolide alleviates parkinsonism in MPTP-PD mice via targeting DRP1-mediated mitochondrial fi

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：zhym821211

【摘要】

：

Our study here aimed to investigate the mechanism and target for how andrographolide protects neurons in Parkinsons disease.Andrographolide administration improved behavioural deficits and attenuated

【作者】

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Liu Wen Geng Ji Gao Jing Guo Wenjie Xu Qiang

【机构】

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State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,163

【出处】

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第十一届全国化学生物学学术会议

【发表日期】

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2019年3期

【关键词】

：

andrographolide mitochondria DRP1 PD

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　　Our study here aimed to investigate the mechanism and target for how andrographolide protects neurons in Parkinsons disease.Andrographolide administration improved behavioural deficits and attenuated loss of dopaminergic neurons in MPTP-exposed mice and reduced cell death induced by rotenone in vitro.

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Andrographolide alleviates parkinsonism in MPTP-PD mice via targeting DRP1-mediated mitochondrial fi

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