【摘 要】
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Objectives: Smooth muscle ceil (SMC) proliferation is a major feature in atherosclerosis, since it contributes to the formation of the fibrous cap, thus to plaq
【机 构】
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LaboratoryofCellularandMolecularBiology,JiangsuProvinceInstituteofTraditionalChineseMedicine
【出 处】
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2014年第十二届全国脂质与脂蛋白学术会议
论文部分内容阅读
Objectives: Smooth muscle ceil (SMC) proliferation is a major feature in atherosclerosis, since it contributes to the formation of the fibrous cap, thus to plaque stability, but also to arterial stenosis and post-angioplasty restenosis.Among the various mitogenic signaling pathways involved in SMC proliferation, the mTOR pathway regulates both the cell cycle and cell growth.Polydatin, a polyphenolic compound from grapes and red wine, has potential anti-atherogenic and anti-cancer properties.This work was designed to investigate the activation of the mTOR pathway by the proatherogenic oxidized LDL (oxLDL) in SMC, and the potential inhibitory eftect of polydatin.
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