Overexpression of miR-19b impairs cardiac development in zebrafish through inhibiting Wnt signaling

来源 :第三届全国斑马鱼研究大会 | 被引量 : 0次 | 上传用户:XX200003
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  The importance of microRNAs(miRNAs)in cardiovascular development is now broadly accepted as crucial regulators and dysregulation of their expression has been linked to cardiac disease.MicroRNA cluster miR-17-92 has been implicated in cardiac development and function,yet its defined mechanisms of action in these contexts are uncertain.We focused on miR-19b,which is a key component of the miR-17-92 cluster proven to induce cardiomyocyte proliferation in vitro.This study aimed to identify its biological significance in cardiac development and underlying molecular mechanisms.
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