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In membrane separation,the introduction of spacers may enhance mass transfer by disturbing the concentration boundary layer.However,the spacers also increase the pressure drop along the channel.A 3D simulation was conducted to describe fluid flow in membrane channels filled with spacers for membrane separation.The CFD results were analyzed in terms of wall shear stress and pressure drop for 1-layer and 2-layer net-type spacers filled channels.The simulation shows that wall shear stress and pressure drop fluctuate for the presence of spacer.Wall shear stress and pressure drop along the channel are affected by the filament orientation significantly.The shear stress and pressure drop increase with the increasing of angle between the filaments,and reach the maximum when the angle is 60o,then the shear stress and pressure drop decrease as angle increases.The simulation also reports that 1-layer spacer shows a promising advantage due to higher shear stress.However,the high pressure drop and production difficulties may restrict the application of 1-layer spacer.The further optimization of 1-layer net-type spacer may lead to a reduction in pressure loss.