【摘 要】
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In the present study,we explore the expression and correlation of survivin with hypoxia related factor HIF-1 α,TGF-β1 and TFE3 in adenoid cystic carcinoma(AdCC).The expression of survivin,HIF-1α,TGF-β
【机 构】
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The State Key Laboratory Breeding Base of Basic Science of Stomatology&Key Laboratory of Oral Biomed
【出 处】
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2014第八次全国口腔颌面-头颈肿瘤学术研讨会
论文部分内容阅读
In the present study,we explore the expression and correlation of survivin with hypoxia related factor HIF-1 α,TGF-β1 and TFE3 in adenoid cystic carcinoma(AdCC).The expression of survivin,HIF-1α,TGF-β1 and TFE3 was assessed by immunohistochemical staining of tissue microarrays containing normal salivary gland(NSG),pleomorphic adenoma(PA)and AdCC.Correlation analysis of these proteins revealed that survivin was significantly increased and associated with over expression of HIF1α(P<0.001,r=0.5599),TGF-β1(P<0.001,r=0.6616),and TFE3(P<0.001,r=0.7747).The expression of Survivin,HIF-1α,TGF-β1 and TFE3 were not correlated with pathological type of human AdCC(P>0.05).Selectively inhibition of survivin by YM155 significantly reduce tumor burden of nude mice xenograft established by implanting cells with observation of the decrease expression of HIF-1α,TGF-β1 and TFE3.The data indicate that over expression of survivin in AdCC is related with hypoxia related factor HIF-1 α,TGF-β1 and TFE3.These findings may provide a rationale for that inhibition of survivin may be a novel strategy for AdCC neoadjuvant chemotherapeutic and radiosensitive application.
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