论文部分内容阅读
Mesenchymal stem cells or multipotent stromal cells (MSCs) ,possessing self-renewal and multipotent differentiation capacities, have been applied for cell-based therapies.Clinical application of MSCs for therapeutic uses requires a great amount of cells.However, ex vivo expansion of MSCs induces cell senescence with loss of stem cell properties.Moreover, there is still lack of knowledge in controlling MSC differentiation in vivo.