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Purpose:Kasabach-Merritt Phenomenon(KMP) is characterized by thrombocytopenia,microangiopathic hemolytic anemia,consumptive coagulopathy and enlarging vascular lesion.It is a rare and life-threatening disease of vascular tumor.The purpose of this study was to assess the effectiveness of absolute ethanol in the treatment of KMP.Methods:we treated eight pediatric patients with KMP by using absolute ethanol injections,whose cases failed previously when applied the Steroids therapy.We reviewed the clinical and laboratory data of these 8 cases at Nanjing Children’s Hospital in China.Results:Eight pediatric patients(5 female and 3 male) showed tumor regression after treatments.Eight patients had been performed core needle biopsy,and the results included seven kaposiform hemangioendotheliomas and one tufted angiomas.All patients had an increase in platelet count.All coagulopathies were corrected.Complications included one patient with flush on face,one patient with needle scars,and one patient with a small area of local tissue necrosis.Conclusion:Absolute ethanol therapy presents a safe option in the treatment of KMP.Treatment-associated complications seemed to be reversible and acceptable by severity levels.Direct intralesional injection of absolute ethanol provides a simple and reliable alternative treatment for KMP among infants and may be used as the second-line therapy.