Objective To evaluate the survival benefit of non-bioartificial liver support system(NBALs) in the treatment of acute or chronic liver failure(ACLF) via a meta-analysis of randomized controlled trials(RCTs).Methods Related databases such as PubMed and EMbase were searched for eligible studies that evaluated the survival benefit of NBALs on Patients with ACLE.Selected studies were evaluated according to the inclusion criteria by two reviewers respectively, followed by data extraction and quality assessment.A meta-analysis was performed in accordance with the Cochrane Systemic Review handbook.The outcome measure was mortality at different follow-up endpoints.The hazard radio(HR) with 95%confidence intervals(Cls) were calculated to assess the survival benefit of of NBALs on patients with ACLK Result Four trials encompassing 1949 participants were included in this meta-analysis.NBALs showed a greater survival benefit(HR=0.78,95%Cl=0.71-0.87) when compared to standard medical therapy(SMT).Conclusion This meta-analysis showed that the survival rate of NBALs was higher than that of SMT.NBALs has obvious effect on survival time of severe hepatitis.NBALs can affect the long-term survival time of ACLF.It is important and necessary to treat these patients with NBALs.