Probing ligand binding modes of Plutella xyllostella cytochrome PxCYP321A1 by homology modeling, mol

来源 :The 10th Conference of Insect Physiology, Biochemistry and M | 被引量 : 0次 | 上传用户：florrie79

【摘要】

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【作者】

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Qingsheng Lin Zhendi Hu Fei Yin Huanyu Chen Zhenyu Li Guohua Zhong Xia Feng

【机构】

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Institute of Plant Protection, Guangdong Academy of Agricultural science,Guangzhou 510640, P.R.China

【出处】

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The 10th Conference of Insect Physiology, Biochemistry and M

【发表日期】

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2013年4期

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The cytochrome P450 family of enzymes (P450) is known to play significant roles in the metabolism of insecticides in many insect species.PxCYP321A1 is one of P450 isoenzymes found in Plutella xyllostella.The results of pre-experimental show that it is likely to involved the resistance of P.xylostella against chlorantraniliprole.In order to understand the mechanisms of ligand binding and interaction between the PxCYP321A1 and chlorantraniliprole, a three-dimensional (3D) model of the PxCYP321A1 was generated based on the crystal structure of the cytochrome P4503A4 by using MODELER module.

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Probing ligand binding modes of Plutella xyllostella cytochrome PxCYP321A1 by homology modeling, mol

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