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Sphingosine kinase 1 (SphK1) is over-expressed in many cancers and therefore serves as a biomarker for cancer prognosis.SKI-5C is a new SphKl inhibitor,and until now its molecular function in Wilms tumor cells has remained unknown.Here,using CCK-8 and nude mice experiments we assessed cell growth in Wilms tumor cell lines (SK-NEP-1 and G401) in vitro and in vivo.