• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. The GSK3-β sensing metabolism controls NLRP3 inflammasome activation

The GSK3-β sensing metabolism controls NLRP3 inflammasome activation

来源 :2016第十一届心血管药理专业委员会全国心脑血管药理学术会议 | 被引量 : 0次 | 上传用户：cninfor
【摘 要】
：
Introduction: Glycogen synthase kinase-3 (GSK3) is composed of two isoforms, GSK3-α and-β, which reveals a new component to function differently in glucose homeostasis and promoting inflammation in mu
【作 者】
：
Shengna Han Lirong Zhang Wajahat Z Mehal Xinshou Ouyang 
【机 构】
：
Section of Digestive Diseases, Yale University, New Haven, CT, USA;Department of Pharmacology, Basic
【出 处】
：
2016第十一届心血管药理专业委员会全国心脑血管药理学术会议
【发表日期】
：
2016年11期
【关键词】
：
GSK3-NLRP3 inflammasome IL-1secretion O-GlcNAc transferase 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Introduction: Glycogen synthase kinase-3 (GSK3) is composed of two isoforms, GSK3-α and-β, which reveals a new component to function differently in glucose homeostasis and promoting inflammation in multiple several prevalent diseases.Aim: To identify the role of GSK3 isoform inhibition on inflammasome activation.Methods: The NLRP3 inflammasome was activated by typical LPS/ATP and host-derived metabolites in primary mouse macrophages.
其他文献
E6AP介导溶酶体参与内皮缺血损伤中紧密连接蛋白降解调控机制
目的:观察缺血条件下内皮细胞中E6AP蛋白表达水平变化,探究E6AP与溶酶体蛋白LAMP2A之间的相互作用,并以此为突破口进一步探索缺血损伤条件下,E6AP介导的溶酶体参与紧密连接蛋白降解途径的机制.方法:体外实验采用内皮细胞系通过糖氧剥夺(Oxygen-glucose deprivation,OGD)模拟缺血损伤,利用免疫印迹方法明确E6AP、LAMP2A、Cathepsin B及紧密连接蛋白水
会议
Neuroprotective effect and mechanism of Mu-Xiang-You-Fang on cerebral ischemia-reperfusion injury in
Ethnopharmacological relevance: The present study is to investigate the neuroprotective effectof Mu-Xiang-You-Fang (MXYF), a classic Traditional Chinese Medicine used by Chinese minorities to treat st
会议
Mu-Xiang-You-Fangcerebral-ischemia reperfusion injuryapoptotic pathway
Cx43 dephosphorylation on serine282 contributes to cardiomyocytes death via activation of p38 MAPK/F
Background: Myocardial ischemia/reperfusion leads to cardiomyocytes death and the generation of various arrhythmias.Cx43 dephosphorylation has been postulated to contribute to the injury of the myocar
会议
The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor
The acute-phase protein orosomucoid (ORM) exhibits a variety of activities in vitro and in vivo, notably modulation of immunity and transportation of drugs.We found in this study that mice lacking ORM
会议
MicroRNA-124 negatively regulates LPS-induced TNF-α production in mouse macrophages by decreasing pr
MicroRNAs play pivotal roles in regulation of both innate and adaptive immune responses.In the present study, we investigated the effects of microRNA-124 (miR-124) on production of the pro-inflammator
会议
Protective effects of circulating microvesicles on myocardial ischemia/reperfusion injury in vivo th
Background aims.Microvesicles (MVs) have been shown to be involved in pathophysiology of ischemic heart diseases (IHD).However, the underlying mechanisms are still unclear.Here we investigated the eff
会议
The protective effect of dioscin-containing serum against hydrogen peroxied-mediated oxidative stres
Objectives: To investigate the effect of dioscin on hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis in cardiomyocytes in vitro and its underlying mechanisms with the method of Serum Ph
会议
碘化N-正丁基氟哌啶醇通过ROS/JNK/Egr-1信号通路拮抗心脏来源的多种细胞缺氧复氧损伤
目的:活性氧(ROS)在细胞内积聚引起的氧化应激是心脏缺血再灌注(I/R)损伤的重要病理生理过程,转录因子Egr-1被认为是再灌注损伤各通路的共同分子基础.本研究在心肌来源H9c2细胞及心脏微血管内皮细胞缺氧复氧(H/R)模型—心脏I/R体外模型上,探讨ROS/JNK/Egr-1信号通路是否存在及对心肌I/R损伤具有一系列保护作用的新化合物N-正丁基氟哌啶醇(F2)是否对此通路具有调节作用.
会议
碘化N-正丁基氟哌啶醇缺氧复氧活性氧早期生长反应基因-1c-Jun氨基末端激酶H9c2细胞心脏微血管内皮细胞
Microvesicles derived from hypoxia/reoxygenation-treated human umbilical vein endothelial cells prom
Background: Vascular endothelial dysfunction is the closely related determinant of ischemic heart disease (IHD).Endothelial dysfunction and ischemia/reperfusion injury (IRI) have been associated with
会议
ORM Promotes Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice
We found previously that acute phase protein orosomucoid reacts to fatigue and activates C-C chemokine receptor type 5 to increase muscle glycogen storage and enhance muscle endurance.To explore the u
会议