Liposome as a carrier of anti-tumor angiogenesis drug has become one of the frontier research topics in cancer therapies,especially for the targeted liposome-mediated delivery.But many current studies on binding of drug carriers to tumor vascular endothelial cells have been largely carried out only under static conditions.Actu ally,physical forces from a flow environment in tumor microcirculation have great influence in the carriers trans port and binding to targeted cells.Drug absorptions measured in a static state are often not applicable to many physiologic flow states.Our studies have focused on effects of different flow conditions on binding and uptake of drug carriers to targeted cells,under tumor physiologic flow conditions.