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Glial scar formation is one of the major consequences of spinal cord injury,which prevents the regenerated axons passing the injured area and forming effective synaptic connection.In this paper,by applying the upconversion nanoparticles coated with polyethylene glycol(PEG)and photosensitizer(UCNPs-PEG-M540)in the injured spinal cord,we used photodynamic therapy(PDT)to reduce the glial scar formation.