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5. Design,synthesis,and Antitumor Activity of novel quinoline and 1,2-dihydroquinoline derivatives conn

Design,synthesis,and Antitumor Activity of novel quinoline and 1,2-dihydroquinoline derivatives conn

来源 :全国药物化学学术会议暨第四届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：cnanjr

【摘 要】

：

A series of novel quinoline and 1,2-dihydroquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized,and evaluated for their c-Met kinase inhibitory activity and antiprolifera

【作 者】

：

Qidong Tang Huafang Lin Chen Xu Pengcheng Li Ping Gong 

【机 构】

：

37＃,Shenyang Pharmaceutical University,103 Wenhua Road,Shenhe District,Shenyang 110016

【出 处】

：

全国药物化学学术会议暨第四届中英药物化学学术会议

【发表日期】

：

2013年11期

【关键词】

：

Synthesis Quinoline c-Met antiproliferative activity 

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论文部分内容阅读

　　A series of novel quinoline and 1,2-dihydroquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized,and evaluated for their c-Met kinase inhibitory activity and antiproliferative activity against 5 cancer cell lines(HT-29,H460,MKN-45,A549,and U87MG)were evaluated in vitro.

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