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  5. mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model

mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户：inksong000
【摘 要】
：
In pilocarpine induced status epilepticus (PISE) in metabotropic glutamate receptor 5 (mGluR5) knock-out (mGluR5-/-) and wild-type (mGluR5+/+) mice,we showed that at 2 h during PISE,induced PKCbeta2 o
【作 者】
：
Jian-Xin LIU Yong-Cheng TANG Yong LIU Feng-Ru TANG 
【机 构】
：
Epilepsy Research Lab, National Neuroscience Institute, Singapore 308433; Institute of Neurobiology
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
【发表日期】
：
2007年12期
【关键词】
：
metabotropic glutamate receptor 5 status epilepticus protein kinase C hippocampu 
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　　In pilocarpine induced status epilepticus (PISE) in metabotropic glutamate receptor 5 (mGluR5) knock-out (mGluR5-/-) and wild-type (mGluR5+/+) mice,we showed that at 2 h during PISE,induced PKCbeta2 or PKCgamma immunopositive product was demonstrated at the border between the stratum oriens and alveus (O/A border) of CA1 area in mGluR5+/+ mice.However,much less staining was observed in mGluR5-/-mice.At 1d after PISE,induced PLCbeta4,PKCbeta2 or PKCgamma in stratum pyramidale of CA1 area in mGluR5+/+ but not mGluR54-mice was found.Double labeling showed co-localization of induced PKCbeta2 or PKCgamma with mGluR5 or induced PLCbeta4 in the stratum pyramidale of CA 1 area.It therefore suggests that induced PLCbeta4-PKCbeta2/PKCgamma at 1 d after PISE in pyramidal neurons or induced PKCbeta2 or PKCgamma at O/A border at 2 h during PISE may be involved in mGluR5-related signal transduction leading to delayed loss of pyramidal neurons in mGluR5+/+ mice.
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