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  5. Inhibition of DNA Methyltransferase as a Novel Therapeutic Strategy to Overcome Acquired Resistance

Inhibition of DNA Methyltransferase as a Novel Therapeutic Strategy to Overcome Acquired Resistance

来源 :2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户：sun0603
【摘 要】
：
Dual PI3K/mTOR(phosphatidylinositol 3-kinase/mammalian target of rapamycin) inhibitors are being evaluated clinically for the treatment of tumors with a hyperactivated PI3K/mTOR pathway.However, unexp
【作 者】
：
Xiao-jun Qian Wen-Dan Chen Gong-Kan Feng Xiao-Feng Zhu Yun-tian Li Yan Yu Yang Fen Rong Deng Jiao Ji Lin Jiao Xuan Li Rui-Yan Wu 
【机 构】
：
State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-Sen University,Guangzhou 51006
【出 处】
：
2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会
【发表日期】
：
2014年5期
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　　Dual PI3K/mTOR(phosphatidylinositol 3-kinase/mammalian target of rapamycin) inhibitors are being evaluated clinically for the treatment of tumors with a hyperactivated PI3K/mTOR pathway.However, unexpected outcomes were obtained in clinical studies of cancer patients with an aberrant PI3K pathway.In clinical trials,applicable combination regimens are not yet available.In this study, using an integrated analysis of acquired BEZ235-resistant nasopharyngeal carcinoma cells, we demonstrate that DNA methyltransferase is a key modulator and a common node upstream of the AKT/mTOR and PDK1/MYC pathways, which are activated in cancer cells with acquired BEZ235 resistance.
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