【摘 要】
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Repetitive transcranial magnetic stimulation (rTMS) has rapidly become an attractive therapeutic approach for stroke.However,its underlying mechanism remains elusive.This study is aimed to investigate
【机 构】
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Department of Rehabilitation Medicine, the Third Affiliated Hospital,Sun Yat-sen University
【出 处】
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第五届粤港澳台物理医学与康复学学术会议暨2014年广东省医学会物理医学与康复学学术会议
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Repetitive transcranial magnetic stimulation (rTMS) has rapidly become an attractive therapeutic approach for stroke.However,its underlying mechanism remains elusive.This study is aimed to investigate whether high-frequency rTMS can promote neurogenesis and to examine the role BDNF-TrkB pathways in rTMS-induced functional recovery in a rat model of middle cerebral artery occlusion.Ischemic rats received either high-frequency rTMS at 20Hz or intermittent theta burst stimulation (iTBS) daily for 2 weeks.High-frequency rTMS and iTBS significantly improved the neurological function and reduced infarct volume.Moreover,High-frequency rTMS and iTBS significantly promoted neurogenesis as evidenced by increased DCX -positive and Ki67/nestin-positive cells in the ipsilateral side.These beneficial effects were in conjunction with the elevation of BDNF and TrkB protein in the peri-infarct region,indicating that high-frequency rTMS promotes neurogenesis and reduces acute ischemic brain damage possibly by the promotion of BDNF signaling pathways.
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