Furo[3',2':3,4]naphtho[1,2-d]imidazole Derivatives as Orally Active and Selective Inhibito

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：curarchy

【摘要】

：

【作者】

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Yeh-Long Chen Chih-Hua Tseng Cherng-Chyi Tzeng

【机构】

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Department of Medicinal and Applied Chemistry,College of Life Science,Kaohsiung Medical University,K

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　The present study describes the synthesis and anti-inflammatory effects of furo [3,2:3,4]naphtho [1,2-d]imidazole derivatives.Among these furo[3,2:3,4]naphtho[1,2-d]imidazole derivatives,2-(4-methoxyphenyl)furo[3,2:3,4]naphtho[l,2-d]imidazole(12) exhibited a strong inhibitory activity on LPS-induced PGE2 production,with an IC50 value of 0.047 μM.

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Furo[3',2':3,4]naphtho[1,2-d]imidazole Derivatives as Orally Active and Selective Inhibito

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