Cancer stemness plays a pivotal role in tumor progression and therapy resistance, representing a great challenge to cancer treatment.With the evolution of cancer stem cell (CSC) model, compelling evidence indicates that cancerstemness tends to be a dynamic feature of cancer cells due to the reprogramming of self-renewal machinery, such as Wnt and Notch pathways.Here, we show that the reduced expression of CD146 induces stem cell-like properties in colorectal cancer (CRC) cells through canonical Wnt signaling.