【摘 要】
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Atrial fibrillation (AF) is the most common form of cardiac dysrhythmia.It increases the risk of death,congestive heart failure,and embolic phenomena including stroke.AF is believed to be a lifetime r
【机 构】
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Departments of Medicine and Physiology The University of Hong Kong Hong Kong SAR China
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Atrial fibrillation (AF) is the most common form of cardiac dysrhythmia.It increases the risk of death,congestive heart failure,and embolic phenomena including stroke.AF is believed to be a lifetime risk in an aging population.Antiarrhythmic drug therapy remains the principal approach for suppressing AF and its recurrence.Class Ⅲ anti-arrhythmic agents are effective in treating AF,but have major limitations,such as inducing severe ventricular arrhythmia (i.e.long QT syndrome).A key objective among the current strategies for suppressing AF is the development of new Class Ⅲ antiarrhythmic agents that preferentially affect atrial rather than ventricular electrical parameters.
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