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Spontaneous canine inflammatory mammary cancer (IMC) shares epidemiologic, histopathological and clinical characteristics with the disease in humans and thereby it has proposed as a natural model for human inflammatory breast cancer (IBC).It has been suggested that some interleukins may participate in sex steroid biosynthesis, invasion and angiogenesis and control of the immune system in human breast cancer.The aim of this study was to asses, by the first time, the serum and tumor content of several interleukins (ILs) (IL-1a, IL-1b, IL-6, IL-8 and IL-10) in dogs with spontaneous inflammatory mammary cancer (IMC), and with other malignant tumors.In Total, thirty-eight dogs that attended atthe Veterinary Teaching Hospital of Madrid were prospectively included in this study.Animals: 7healthy Beagles (control, NMG), 24 cancer-bearing dogs with non-inflammatory malignant mammary tumors (nonIMC) and 7 dogs clinically diagnosed with IMC.The ILs analysis was performed in sera and hom.ogenated tissue samples using the Evidence Investigator, a semi-automated Biochip Array Technology analyzer (Randox Laboratories).